Heterogeneous Time Dependent Static Light Scattering (HTDSLS)

Principle: Use flow to create countable scattering peaks from colloidal particles, while simultaneously monitoring the background scattering due to co- existing polymers

• Determine large particle densities amid polymer chains; e.g. spherulites, microgels, bacteria, crystallites, etc.
• Follow evolution of large particles; e.g. in biotechnology reactors where bacteria/polymers co-exist. e.g. xanthan productions, degradation of polysaccharides, other fermentation reactions;
• Permits useful characterization of polymers in solutions which, up until now, would be considered far too contaminated with dust and other scatterers.

Applications of HTDSLS

1. Good data from a classically intractable case of high particulate contamination: 5200, 2mm latex spheres/mL

2. Co-existing E. Coli and PVP polymers in solution

Publications

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